Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is marked by (primarily ovarian) hyperandrogenemia and ovarian dysfunction. In many cases, PCOS first manifests during adolescence, and both peripubertal hyperandrogenemia and obesity are considered risk factors for the development of PCOS. Many, but not all, pubertal girls with obesity – including those in early puberty – exhibit relative hyperandrogenemia. However, the causes of peripubertal obesity-associated hyperandrogenemia, and...